Lyndsy Simon

Harrison, Arkansas · Remote · lyndsy@lyndsysimon.com · lyndsysimon.com

Summary

Principal software engineer, living and breathing technology since 2007. Four and a half years at Modern Health ending as Senior Staff Engineer, where I was responsible for the event-driven backbone most of the product ran on and where I did the org’s early AI work: developer tooling, agentic code generation, and user-facing features. Most recently Principal Software Engineer at Blueprint, where I built and shipped Immortals Intelligence, a clinician-facing AI platform for finding novel correlations in patients’ full medical histories. Python-first, with Ruby, JavaScript, and SQL in regular use, and a habit of owning a system from design through on-call.

Experience

Blueprint — Principal Software Engineer

Dec 2025 – Oct 2026 · Remote

AI for biological aging.

• Led development of Immortals Intelligence, a clinician-facing application for organizing, analyzing, and drawing insights from a patient’s complete medical history.
• Built AI agents on LangGraph/LangChain that scanned patient biomarker and intervention data for novel correlations, classifying each finding against the published literature as supported, refuted, or previously undiscussed.
• Ranked findings by statistical strength, novelty, and impact on critical biomarkers, surfacing the strongest to clinicians for review and follow-up.
• Shipped the platform to production with EMR integrations including Healthie and MedPlum, on AWS infrastructure I designed end to end.
• The first user was the founder; by the end of my tenure, roughly a dozen patients were enrolled in the $1M/year Immortals program — a ~$12M annual subscription business for which the platform was a core dependency.

Modern Health — Senior Staff Software Engineer

Mar 2021 – Dec 2025 · Remote

• Responsible for the asynchronous event-driven system underlying a microservice architecture, end to end: ideation, vendor and tool selection, implementation, rollout, advocacy, and ongoing maintenance.
• Built on Amazon EventBridge with a small set of bespoke integration libraries that enforced consistent usage across teams, plus comprehensive documentation maintained as part of the system rather than after it.
• Worked across platform, dev/ops, infrastructure, monitoring and alerting, data engineering, and process design.
• AI focus across the organization: internal developer tooling, agentic code generation, integration into existing business processes, and user-facing AI features.
• Advocate for an intentional, functional, and empathetic engineering culture.

Carbon Health — Senior Software Engineer

May 2020 – Dec 2020 · Remote

GoodRx — Senior Software Engineer

Mar 2018 – Oct 2019 · Remote

• Part of a small team responsible for GoodRx Gold, the subscription product, with a primary focus on long-term stability as it grew from an internal experiment into a strategic part of the company’s business.
• Shipped the first white-label deployment, coordinated with a major national pharmacy chain; the launch went smoothly and the project succeeded for everyone involved.

Locus Health — Software Developer

Oct 2016 – Jan 2018 · Remote

• Communications system for parents of infants born with a specific congenital heart defect: an iOS app on company-provided iPads, integration with electronic medical records, and a Ruby on Rails service mediating between the two.

Muster Software — Software Engineer

Dec 2015 – Jul 2016 · Remote

• New features and maintenance on a legacy Django application that let organizations with large contact lists segment communications by the physical location of their contacts and match them to legislators at the local, state, and federal level.
• Built the counterpart platform that let recipients of those communications reach their representatives through a single interface, including schema generation and automated form submission for legislators whose contact systems had no API.

Center for Open Science — Developer

May 2013 – Dec 2015 · Charlottesville, VA

• Worked on the flagship product, the Open Science Framework, across a Python/Flask application, Elasticsearch, Docker, and third-party monitoring and analysis tooling. Implemented an ORM supporting several database backends.

FedEx Freight — Senior Analyst, Systems & Performance Support

Mar 2007 – May 2013 · Harrison, AR

• Data acquisition and analysis in support of strategy initiatives and at the direction of executive leadership.
• Content and front-end work on a corporate intranet serving roughly 40,000 users, in PHP, raw JavaScript, and jQuery. If it was on the intranet and it broke, it was mine to fix.

Shooters’ Journal — Co-founder

Dec 2010 – Dec 2015

Open Source

• bip32utils — BIP32 hierarchical deterministic wallet utilities for Python. 2014, still in use.
• Contributions — diff-cover, nimble (Nim package manager), early Gittip.

Certifications

• DeepLearning.AI — Generative AI for Software Development, 2025
• FAA — Remote Pilot, Part 107, 2020
• Triplebyte — Certified Generalist Software Engineer, 2020
• CompTIA — A+ (2008–2014), Project+ (2012)
• CIW — v5 Associate, Database Design Specialist, JavaScript Specialist, Web Design Specialist (2010–2013)

Business Ownership

Simon Photography & Design — Owner

2004–2009

Ascend Photography — Owner

2020–present

Commercial and drone photography. FAA Part 107 certified. Runs alongside engineering work, not instead of it.